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Received:August 29, 2022 Published Online:May 20, 2023
Received:August 29, 2022 Published Online:May 20, 2023
中文摘要: 目的 探讨经腹超声黏膜下层指数（黏膜下层厚度/总肠壁厚度×100%）对溃疡性结肠炎（UC）患者治疗反应性的早期预测价值。方法 纳入2019年2月至2020年3月厦门大学附属东南医院135例UC患者,均接受结肠镜检查及经腹超声黏膜下层指数评估,治疗后采用结肠镜评估患者的治疗反应性,并根据治疗反应性分为缓解组（n=94）和未缓解组(n=41),〖JP+1〗分析经腹超声黏膜下层指数对治疗反应性的早期预测价值。结果 经腹超声黏膜下层指数高（OR=1.854）、UC内镜下严重程度指数（UCEIS）高（OR=1.605）、超敏C反应蛋白水平高（OR=1.332）及黏膜下层厚度高（OR=1.838）均为UC患者治疗反应性欠佳的独立危险因素（P<0.05）；ROC曲线及Delong分析显示经腹超声黏膜下层指数预测UC患者治疗反应性的ROC曲线下面积高于黏膜下层厚度、超敏C反应蛋白及UCEIS评分（P<0.05）。结论 经腹超声黏膜下层指数对UC患者治疗反应性具早期预测价值。
Abstract:Objective To investigate the early predictive value of transabdominal ultrasonography submucosa index（submucosa thickness to total bowel wall thickness ratio） for treatment responsiveness in patients with ulcerative colitis（UC）. Methods A total of 135 UC patients in the Affiliated Dongnan Hospital of Xiamen University from February 2019 to March 2020 were included, and all subjects underwent colonoscopy and transabdominal ultrasound submucosa index evaluation. After treatment, colonoscopy was used to evaluate the treatment responsiveness of patients, and patients were divided into remission group(n=94) and non-remission group(n=41) according to the treatment responsiveness. The early predictive value of transabdominal ultrasound submucosa index on treatment responsiveness was analyzed. Results High transabdominal ultrasound submucosa index（OR=1.854）, high UCEIS score（OR=1.605）, high hypersensitice C-reactive protein（OR=1.332） and high submucosal thickness（OR=1.838） were risk factors for poor treatment response in UC patients（P<0.05）. ROC curve and Delong analysis showed that the area of ROC transabdominal ultrasound submucosa index for predicting treatment response in UC patients was higher than that of submucosa thickness, hypersensitivity C-reactive protein and UCEIS score（P<0.05）. ConclusionTransabdominal ultrasound submucosa index has early predictive value for treatment responsiveness in UC patients.
keywords: Ulcerative colitis Treatment responsiveness Transabdominal ultrasound Submucosa index Submucosal thickness Total bowel wall thickness Hypersensitive C-reactive protein Ulcerative colitis endoscopic index of severity
文章编号： 中图分类号：R574.1 文献标志码：A
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