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Received:September 09, 2022 Published Online:April 20, 2023
Received:September 09, 2022 Published Online:April 20, 2023
中文摘要: 近年来,恶性肿瘤的发病率逐年上升,严重危害人类的健康。上皮—间质转化（EMT）在恶性肿瘤侵袭和转移中发挥了关键作用,Wnt、NF-κB、PI3K、TGF等信号通路以及表皮生长因子（EGF）和微小核糖核酸（miRNA）等均参与了EMT的形成过程。本文结合以上信号通路及相关因子对EMT在各系统恶性肿瘤发病和侵袭转移中的作用做简要综述。
中文关键词: 上皮—间充质转化 信号通路 微小核糖核酸 表皮生长因子；恶性肿瘤
Abstract:In recent years, the incidence of malignant tumors is increasing year by year, which seriously endangers human health. Epithelial-mesenchymal transformation（EMT） plays a key role in the invasion and metastasis of malignant tumors. Wnt, NF-κB, PI3K, TGF and other signaling pathways, epidermal growth factor（EGF） and microribonucleic acid（miRNA） are involved in the formation of EMT. This article will briefly review the role of EMT in the pathogenesis, invasion and metastasis of malignant tumors in various systems by combining the above signaling pathways and related factors.
keywords: Epithelial-mesenchymal transition Signaling pathway MicroRNA Epidernal growth factor Malignant tumor
文章编号： 中图分类号：R730 文献标志码：A
基金项目:内蒙古自治区高等学校科学研究项目（NJZZ22651）;内蒙古医疗卫生科技计划项目（20201331）
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