Abstract:Objective To explore the clinical effects of pre-colonoscopic intestinal preparation schemes optimized according to Bristol stool form scale（BSFS） typing. Methods The clinical data of 150 patients received colonoscopy in the First Affiliated Hospital of Anhui Medical University from May 2020 to January 2021 were retrospectively analyzed. According to the Bristol stool form type and medication regimen, the patients were divided into three groups（n=50, each）: group A （Bristol 1~4）, group B （Bristol 1~4） and group C （Bristol 5~7）. 1.5L polyethylene glycol and electrolyte oral solution（PEG-ELS） were used in three groups，and prucalopride 2 mg was added one day before examination in group A. Boston bowel preparation scale（BBPS）, total bowel preparation rate, polyp detection rate（PDR）, adverse reactions rate and patients acceptance rate were compared among three groups. Results The total BBPS score in group A was significantly higher than that in group B（6.50±0.79 vs 5.58±0.81, P＜0.05） and was similar to that in group C（6.50±0.79 vs 6.32±0.79, P＞0.05）. The successful rates of intestinal preparation in group A（92.00%）and group C（80.00%） were significantly higher than that in group B（58.00%, P＜0.05）. There were no significant differences in patients acceptance rate,PDR and adverse reactions among three groups（P ＞0.05）. Conclusion Intestinal preparation according to BSFS is simple and effective. The reduced amount of PEG-ELS（1.5L） has a high acceptance rate and fewer adverse reactions, which can significantly improve the effect of intestinal preparation in combination with prucalopride for the patients of BSFS score 1-4.