Abstract:Objective To explore the pathological characteristics and the clicical experience in diagnosis and treatment of bladder paraganglioma. Methods The clinical data of 8 patients with bladder paraganglioma admitted to Xijing Hospital of Air Force Military Medical University from August 2011 to April 2022 were analyzed retrospectively. Results There were 4 males and 4 females, with a mean age of 55.1 years ranging from 31 to 73 years. Out of 3 cases of bladder paraganglioma complicated with hypertension, 1 case had elevated blood pressure during urination. Among 8 patients, there were 2 cases with hematuria, 2 cases with frequent and urgent urination, 1 case with dizziness and palpitation and 3 asymptomatic cases. All 8 patients received surgical treatment,including 4 cases treated with partial cystectomy and 4 cases treated with transurethral resection of bladder tumors. Two cases were confirmed before operation, and 3 cases had sharp increase of blood pressure during operation. Immunohistochemistry showed that CD56, chromogranin A（CgA） and synaptophysin（Syn） were positive in all patients. No recurrence or metastasis occurred in the patients who were followed up for 3 months to 10 years after operation. Conclusion Bladder paraganglioma is a rare disease and is difficult to diagnose before operation. CT and cystoscopy can improve the diagnosis based on localization. The urinary vanillyl-mandelic acid（VMA）and catecholamine levels can be measured for qualitative diagnosis. Definite diagnosis depends on pathological and immunohistochemical examination after operation. Surgical resection is the first choice of treatment, and long-term follow-up is required after operation.