Abstract:Objective To investigate the feasibility and effect of enhanced recovery after surgery（ERAS） protocol in the perioperative period of laparoscopic appendectomy（LA） for the elderly patients with acute appendicitis. Methods A retrospective analysis was performed on the data of 252 elderly patients with acute appendicitis treated in the Affiliated Hospital of Chengde Medical University from January 2016 to October 2020. There were 108 patients received LA from January 2016 to December 2017 in traditional group（n=108） and 144 cases received LA with ERAS from January 2018 to October 2020 in ERAS group. The postoperative anal exhaust time, defecation time, the first out-of-bed activity time and the first time to eat ordinary food, hospitalization time as well as the incidence of postoperative complications were compared between two groups. Results There was no significant difference in general data between two groups（P＞0.05）. The postoperative anal exhaust time, defecation time, the first out-of-bed activity time, the first time of eating ordinary food and hospitalization time were significantly shortened（P＜0.01）, and the incidence of pulmonary infection reduced in ERAS group compared with those in control group（P ＜0.05）. There was no significant difference in the incidence of other post-operative complications and unplanned reoperation and readmission within 30 days between two groups（P＞0.05）. Conclusion ERAS scheme has advantages over traditional perioperative management and is safe and feasible in LA, with the incidence of complications and readmission rate similar to those of conventional treatment.