Abstract:Objective To analyze the related risk factors of early acute traumatic coagulopathy（ATC） secondary to trauma in order to provide references for the prevention, treatment, and prognosis of ATC in patients with severe trauma. Methods The clinical data of trauma patients hospitalized in the First Affiliated Hospital of Soochow University from January 1 to December 31, 2020 were retrospectively collected. The trauma patients were divided into ACT group（secondary ACT, n=35） and NO-ATC group（without ATC, n=147） according to the clinical diagnosis criteria of acute post-traumatic coagulopathy. Multivariate logistic regression model was used to analyze the influencing factors of secondary ATC in trauma patients. Results Among 182 trauma patients collected, 19.2% were secondary to ATC and 80.8% were not associated with ATC. There were statistical differences in age, injury severity score（ISS）, Glasgow coma scale（GCS）, trauma index（TI）,body temperature, shock index（SI）,platelet count, hemoglobin, albumin, creatinine and the time of first transfusion（more than 24h） between two groups（P＜0.05）. Multivariate logistic regression analysis showed that age, TI score, albumin and the time of first blood transfusion（more than 24 hours） were the independent influencing factors of secondary ATC in patients with severe trauma（P＜0.05）. Conclusion Age, TI score, albumin and time of first blood transfusion>24 hours were independent influencing factors of secondary ATC in patients with severe trauma. The more attention should be payed to the early intervention measures for the patients with the severity of trauma, so as to reduce the incidence of ATC and to improve the prognosis of severe trauma patients in clinical emergency work.