Abstract:Objective Based on knowledge visualization analysis, to investigate the global research status and trend of sepsis-induced acute lung injury（ALI） to provide reference basis for further research in this field. Methods By searching the literature on sepsis-induced ALI from 2013 to 2022 in Web of Science Core Collection（WoSCC） database, the Excel was used to analyze the relevant literature. The software VOS viewer and CiteSpace were used to extract the relevant information and generate the co-occurrence network so as to further explore the hot issues in the field of sepsis-induced ALI and analyze the research status and development trend of it. Results A total of 3216 effective literatures of sepsis-induced ALI were included in the WoSCC database from 2013 to 2022. There was an overall increasing trend of sepsis-induced ALI related studies worldwide. China was the country with the highest number of published literature related to ALI in sepsis. The organization with the largest number of papers was the University of California, San Francisco（UCSF）. The largest number of publications in the relevant fields of research were published in Shock journal. The co-occurrence network analysis showed that the United States was the country mostly involved in international collaborations in this field,and UCSF was the most collaborative institution. Keyword co-occurrence analysis and co-cited literature clustering analysis showed that the research hotspots in this field mainly focused on the pathological mechanism and treatment strategy of ALI in sepsis. Conclusion Global trend analysis suggests that the research on sepsis-induced ALI is growing day by day during the decade of 2013—2022, and the pathogenesis and treatment strategies of sepsis-induced ALI will continue to be the focus of future research. However, the cross-regional inter-agency communication and cooperation are still insufficient and need to be further explored for the depth and breadth of research.