Abstract:Objective To investigate the clinical value of narrow band imaging (NBI) combined with endoscopic submucosal dissection (ESD) in the treatment of early colorectal cancer (CRC). Methods A retrospective analysis was performed on the clinical data of 101 patients with early CRC undergoing ESD at the Fourth Affiliated Hospital of China Medical University from January 2018 to December 2020. The patients were divided into NBI group (n=54) and white light endoscopy (WLE) group ( n=47) according to different preoperative examination methods. Baseline characteristics, ESD-related indicators, postoperative pathology and additional surgery were compared between two groups. Results In NBI group, the positive vertical margin rate was lower than that in WLE group (1.9% vs 12.7%, P<0.05), the complete resection rate was higher than that in WLE group (96.3% vs 83.0%, P<0.05), and the rate of additional surgery was lower than that in WLE group (1.9% vs 12.7%, P<0.05).Conclusions In the treatment of early CRC, NBI combined with ESD can effectively reduce the positive vertical margin rate and the risk of additional surgery and increase the complete resection rate of tumor.