Abstract:Objective To evaluate the effect of endoscopic mucosal dissection (ESD) in the treatment of early gastric cancer. Methods A retrospective analysis was performed on the clinical data of 155 patients with early gastric cancer who underwent ESD in Anqing First People's Hospital from December 2018 to June 2021 to evaluate the efficacy and safety of ESD for early gastric cancer. Results Among 155 cases, the mean lesion size was (1.55±0.38）cm, the operation time was (59.20±14.83）min, and the hospital stay was (5.00±1.21)d. The additional surgery was conducted in 13 cases because of the depth of invasion of cancer tissue being more than 500μm in the submucosa. There were 2 cases of early bleeding, 5 cases of delayed bleeding, 3 cases of cardio stenosis, 1 case of pyloric stenosis and no perforation occurring. The complication rate was 7.10%（11/155）. Endoscopic reexamination suggested the wound healing rate was 100% at 6 months after operation. The local recurrence rate was 0 during 1 year follow-up.Conclusions In the treatment of early gastric cancer, ESD has the advantages of rapid recovery, fewer complications and short hospitalization time and is also suitable for grass-roots hospitals.