Abstract:Objective To investigate the clinical value of ultrasound-guided localization in the early diagnosis of breast tumors. Methods A total of 626 cases of breast tumors with ultrasound-guided localization biopsy were collected in Shaanxi Cancer Hospital from January 2014 to December 2017 to analyze the correlation between ultrasonographic features and clinicopathological parameters. Results There were 252 cases of breast cancer (11 cases of intraductal carcinoma and 241 cases of invasive carcinoma), 53 cases of precancerous lesions and 321 cases of benign lesions, and precancerous lesions and breast cancer accounted for 48.72% (305/626). The pathological stages were stage 0-Ⅰ in 87 cases, stage Ⅱ in 126 cases and stage Ⅲ in 39 cases, with 34.52% of stage 0-Ⅰ (87/252). There were significant differences in tumor diameter, boundary, shape, internal echo, calcification characteristics, blood flow signal, capsule, axillary lymph nodes and BI-RADS grading between benign and malignant lesions (P<0.05). There were statistical differences in tumor morphology, internal echo, calcification and blood flow signal among the tumors with different diameters (P<0.05) and in tumor morphology, internal echo and BI-RADS grading in the tumors at different TNM stages (P<0.05). There were significant differences in BI-RADS grading between the metastatic and invasive tumors and those without lymph node metastasis and invasion (P<0.05). There were significant differences in the tumor cell envelope characteristics between the invasive carcinoma group and the non-invasive carcinoma group (P<0.05). There was no significant differece in the ultrasonic morphological characteristics among different histological grades of breast carcinoma (H=2.086, P=0.353). Conclusion Ultrasound-guided localization has important clinical value in the early diagnosis of breast tumors.