本文已被:浏览 491次 下载 353次
Received:May 09, 2022 Published Online:September 20, 2022
Received:May 09, 2022 Published Online:September 20, 2022
中文摘要: 目的 探讨术前淋巴细胞/单核细胞比值(LMR)与浸润性乳腺癌临床病理特征及预后的关系。方法 回顾性分析 2013年1 月 1日至2017年12月31日在吉林大学第二医院诊断为浸润性乳腺癌135例患者的临床资料。运用ROC曲线获得LMR的截断值,根据截断值分为高LMR组和低LMR组,采用Kaplan-Meier生存分析法比较两组患者3年的无病生存(DFS),进行Cox多因素回归分析以确定浸润性乳腺癌的独立预后因素。结果 LMR预测DFS的最佳截断值为5.45,约登指数为0.312时,敏感度为85.7%,特异度为45.5%;不同LMR分组与年龄、雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER2)、Ki-67、淋巴结状态差异无统计学意义(P>0.05)。单因素分析显示LMR≤5.45、HER2阳性及淋巴结转移数≥4个是影响浸润性乳腺癌3年DFS的危险因素(P<0.05)。Cox多因素分析显示LMR和淋巴结转移数是影响浸润性乳腺癌预后的独立因素(P<0.05)。结论 浸润性乳腺癌患者术前外周血低LMR是影响患者预后的独立危险因素,LMR值与预后呈正相关,可作为评估预后的指标。术前LMR与浸润性乳腺癌的临床病理特征无关。
Abstract:Objective To investigate the associations of preoperative lymphocyte-to-monocyte ratio (LMR) with clinicopathological characteristics and prognosis of breast cancer. Methods A retrospective analysis was performed on the clinical data of 135 invasive breast cancer patients treated in the Second Hospital of Jilin University from January 1, 2013 to December 31, 2017. According to the cut-off value of LMR in the ROC curve analysis, the patients were divided into high LMR group (LMR>5.45) and low LMR group (LMR ≤5.45). Kaplan-Meier survival analysis was used to compare 3 years-disease-free survival (DFS) between two groups. Cox multifactor regression analysis was performed to identify independent prognostic factors for invasive breast cancer. Results The optimal cut-off value of LMR for predicting DFS was 5.45. The sensitivity was 85.7%, and the specificity was 45.5% as Jorden index was at 0.312. There was no significant difference in age, estrogen receptor (ER), progesterone receptor(PR), human epidermal growth factor receptor-2(HER2), Ki-67 and lymph node status between two groups (P>0.05). Univariate analysis showed that LMR ≤5.45, HER2 positivity and≥4 lymph node metastases were the risk factors influencing 3 years-DFS of invasive breast cancer(P<0.05). Cox multifactorial analysis showed that LMR and lymph node metastases were the independent factors affecting the prognosis of invasive breast cancer(P<0.05). Conclusion In the patients with invasive breast cancer, preoperative low LMR in peripheral blood is an independent risk factor for poor prognosis. LMR is positively correlated with prognosis and can be used as an indicator to assess prognosis. Preoperative LMR is not related with clinicopathological features of invasive breast cancer.
keywords: Lymphocyte-to-monocyte ratio Invasive breast cancer Inflammatory factor Diseasefree survival Clinicopathological feature Prognosis
文章编号: 中图分类号:R737.9 文献标志码:A
基金项目:
Author Name | Affiliation |
SUN Lin, LIU Jia-jia, YIN Guang-hao, WANG Dan | Department of Breast Surgery, the Second Hospital of Jilin University, Changchun, Jilin 130041, China |
Author Name | Affiliation |
SUN Lin, LIU Jia-jia, YIN Guang-hao, WANG Dan | Department of Breast Surgery, the Second Hospital of Jilin University, Changchun, Jilin 130041, China |
引用文本: