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Received:April 10, 2022 Published Online:July 20, 2022
Received:April 10, 2022 Published Online:July 20, 2022
中文摘要: 糖尿病胃轻瘫（DGP）是一种以非梗阻性胃排空延迟为特征的糖尿病常见并发症，其发病机制一直以来备受国内外学者的关注。相关研究表示Cajal间质细胞（ICC）的数量与功能异常可导致胃动力障碍，而干细胞因子（SCF）/酪氨酸激酶受体（c-kit）通路可直接调控ICC的数量与表型。在治疗方面，有研究显示针灸可通过SCF/c-kit通路调控ICC表型以治疗DGP。目前，SCF/c-kit信号通路、ICC、DGP之间关系尚未明了，本文旨在探讨针灸与三者之间作用的关系，并对国内外近期研究进行总结，以期为针灸治疗DGP提供参考。
中文关键词: 干细胞因子/酪氨酸激酶受体通路 Cajal间质细胞 糖尿病胃轻瘫 针灸
Abstract:Diabetic gastroparesis（DGP） is a common complication of diabetes characterized by non-obstructive gastric empting delay, and its pathogenesis has been studied by scholars at home and abroad. Related studies have shown that abnormal number and function of interstitial cells of Cajal （ICC）can lead to gastric motility disorders, and stem cell factor (SCF)/tyrosine kinase receptor (c-kit) pathway can directly regulate the number and phenotype of ICC. In treatment, studies have shown that acupuncture can regulate the phenotype of ICC through the SCF/c-kit pathway to treat DGP. At present, the relationship between SCF/c-kit pathway signaling pathway, ICC and DGP is not clear, therefore, the purpose of this paper is to explore the relationship between acupuncture and the three, and to summarize recent studies at home and abroad, in order to provide reference for acupuncture treatment of DGP.
keywords: Stem cell factor (SCF)/tyrosine kinase receptor (c-kit) pathway Cajal interstitial cells Diabetic gastroparesis Acupuncture
文章编号： 中图分类号：R587.2 R246.1 文献标志码：A
基金项目:第六批全国老中医药专家学术经验继承工作项目（国中医药人教发［2017］29号）
| Author Name | Affiliation |
| GUO Xin-yi*， LIU Chang-xing， HUANG Ya-hui | *Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712000, China |
| 刘长兴1 | 1. 陕西中医药大学，陕西 咸阳712000； |
| 黄雅慧2 | 2. 西安市中医医院脾胃病科，陕西 西安710021 |
| Author Name | Affiliation |
| GUO Xin-yi*， LIU Chang-xing， HUANG Ya-hui | *Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712000, China |
| 刘长兴1 | 1. 陕西中医药大学，陕西 咸阳712000； |
| 黄雅慧2 | 2. 西安市中医医院脾胃病科，陕西 西安710021 |
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