Abstract:Pyroptosis is inflammatory cell death mediated by Gasdermin family, mainly mediated by Gasdermin D（GSDMD）. Activated caspase-1/4/5/11 cuts common substrate GSDMD after activation of inflammasome, which promotes the release of inflammatory substances. Pyroptosis plays an important role in the development of diabetes mellitus and its complications through the cascade of inflammation. Some potential molecules targeting the pyroptosis and inflammasome signaling pathways could be a novel therapeutic avenue for managing and treating diabetes and its complications in the near future. This paper summarise the current understanding of the molecular mechanisms associated with pyroptosis, as well as recent advances in the role of pyroptosis in the development of diabetic complications.