Abstract:Nowadays, the outbreak of the novel coronavirus disease-2019 (COVID-19) in the world has attracted widespread attention at home and abroad. Studies have shown that the receptor that mediates cross-species transmission of 2019-new coronavirus (2019-nCoV) is consistent with SARS-CoV, both of which are angiotensin converting enzyme-2 (ACE2). The renin-angiotensin system (RAS) is a key humoral regulation system in the body and plays an important role in the regulation of cardiovascular function homeostasis and water-electrolyte balance. Under the situation of national anti-epidemic, the research on 2019-nCoV and RAS system has attracted attention from clinicians. This article will review the current hot topics, including COVID-19, ACE2, ACE inhibitor (ACEI)/angiotensin receptor blocker (ARB) drugs and their related research progress.