Abstract:ObjectiveTo investigate the clinical efficacy of ultrasound-guided paravertebral block combined traditional Chinese medicine in patients with postherpetic neuralgia. Methods A total of 60 patients with thoracic postherpetic neuralgia who were treated in the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine from January 2017 to January 2021 were selected and randomly divided into observation grouP( n =30, ultrasound-guided paravertebral block combined with Xuefu Zhuyu Decoction) and control grouP( n =30, oral treatment with Gabapentin Capsules). Before treatment, 1 week, 2 weeks, 1 month, 2 months and 3 months after treatment, the visual analog scale (VAS) and Pittsburgh SleePIndex (PSQI) were used to evaluate the clinical efficacy, and the adverse reactions of patients during treatment was recorded. Results One week, 2 weeks, 1 month, 2 months and 3 months after treatment, the VAS and PSQI scores of the two groups were decreased, and the observation grouPwas significantly lower than the control grouP(P<0.05). The incidence of dizziness, drowsiness and other adverse reactions in the observation grouPwas lower than that in the control grouP(P<0.01). The total effective rate (96.7% vs 73.3%, P<0.01) and markedly effective rate (90.0% vs 56.7%, P<0.05) of the observation grouPwere higher than those of the control group, and the difference was statistically significant. Conclusion Ultrasound-guided paravertebral block combined with traditional Chinese medicine in the treatment of postherpetic neuralgia has a rapid onset, significant analgesic effect, and small side effects.