Abstract:ObjectiveTo assess the influence of goal-oriented anesthesia management on regional cerebral oxygen saturation (rSO2) for the wake-uPtest of scoliosis surgery in adolescents. Methods A total of 86 adolescent patients scheduled for scoliosis surgery were selected and randomly assigned into rSO2 goal-oriented anesthesia management grouP(T group, n =43) and control grouP(C group, n =43). The rSO2 value was monitored during operation and maintained its decline at lower than 10% of the baseline in T group, and the routine anesthesia management was conducted in C group. The degree of hypoxia was evaluated based on the change of intraoperative rSO2 value, the number of cases of cerebral hypoxia before awakening and after operation were recorded, and the area under ROC curve (AUC) was calculated for the patients with a intraoperative rSO2 decrease of more than 10% of the baseline value. The arousal time, Ramsay Sedation score and Rikerz agitation score were recorded and observed to evaluate the quality of arousal from anesthesia. The anesthesia recovery related indexes were also recorded after operation. Results No severe cerebral hypoxia occurred before awakening and during operation in both groups. The degree of cerebral hypoxia in T grouPwas lower than that in C grouP(P<0.05), and the AUC of rSO2 decreased by more than 10% before awakening and during operation in T grouPwas significantly lower than that in C grouP(P<0.05). Compared with C group, the Ramsay score in T grouPwas higher ［3(1) vs 2(2), χ2 =7.75, P<0.01］, the Riker score in T grouPwas lower ［4(1) vs 5(1), χ2 =9.81, P<0.01］. Compared with those in C group, higher wake-uPquality, shorter wake-uPtime, shorter PACU residence time and lower incidence of delirium in wake-uPperiod were observed in T grouP(P<0.05). Conclusions For the adolescent patients with scoliosis surgery, rSO2 goal-oriented anesthesia can effectively avoid the long-term brain hypoxia exposure by adjusting the measures in anesthesia, enhance the protection of brain and reduce the occurrence of perioperative neurocognitive disorder, which is conducive to improve the quality of intraoperative arousal, shorten the arousal time, promote postoperative recovery, and improve the safety and quality of anesthesia.