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Received:August 16, 2021 Published Online:May 20, 2022
Received:August 16, 2021 Published Online:May 20, 2022
中文摘要: 目的 分析青岛市社会组织(CBO)陪同转介治疗模式在男性同性性行为(MSM)人群艾滋病(AIDS)快速抗病毒治疗(ART)中的效果,为后续相关工作和政策制定提供参考。方法 采用回顾性研究方法,收集2019年青岛市某CBO陪同转介治疗服务的经MSM传播的HIV感染者和AIDS患者的基线和抗病毒治疗后的相关资料,分析评估ART效果。结果 共纳入150例。接受CBO陪同转介治疗服务的HIV感染者/AIDS患者用药天数3(1,6)d,基线、治疗6个月、12个月CD4+T淋巴细胞计数分别为412.3(376.0~450.0)、603.8(549.6~666.9)、613.2(558.6~666.9)个/μl,三个时间比较差异有统计学意义(P<0.01)。与其他开展ART机构相比,CBO陪同转介治疗服务的患者7 d内服药率显著提高、服药天数显著降低,抗病毒治疗率、治疗6、12个月CD4+T淋巴细胞检测率和病毒载量检测率显著增加,差异均有统计学意义(P<0.01)。结论 CBO陪同转介治疗模式有利于缩短ART开始时间,显著提高HIV感染者/AIDS患者的治疗率、服药依从性以及随访质量。
Abstract:Objective To analyze the role of Qingdao community-based organizations (CBO) accompanying treatment model in the rapid initiation of antiretroviral therapy (ART) for HIV/AIDS patients of men who had sex with men(MSM), providing reference for subsequent related work and policy formulation. Methods A retrospective analysis was conducted to evaluate ART effects based on the collected baseline and post-antiviral treatment data of HIV infected persons and AIDS patients (HIV/AIDS patients) receiving escorted services by CBO in Qingdao in 2019. ART effect was evaluated. Results A total of 150 cases was enrolled. The average administration days were 3(1,6) days. The CD4+T lymphocyte counts were 412.3 (376.0-450.0), 603.8 (549.6-666.9) and 613.2 (558.6-666.9)/μl, respectively at baseline and after 6 and 12 months of treatment. There were significant differences in them among the three time points (P<0.01). Compared with other ART methods, the rate of 7-day oral administration was significantly increased, the number of days medication was significantly reduced and the rate of antiviral treatment, detection of CD4+ T lymphocyte and detection rate of virus load were significantly increased at 6 and 12 months of treatment for the patients with escorted services by CBO (P<0.01). ConclusionThe escorted services by CBO is helpful to shorten the start time of ART and improve the therapeutic qualities, medication maintenance and quality of life of MSM-HIV infected/AIDS patients.
keywords: Acquired immune deficiency syndrome Rapid initiation of antiretroviral therapy Escorted services Community-based organizations Men who have sex with men
文章编号: 中图分类号: 文献标志码:A
基金项目:“十三五”国家科技重大专项艾滋病专项(2018ZX10721102)
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