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Received:September 16, 2021 Published Online:May 20, 2022
Received:September 16, 2021 Published Online:May 20, 2022
中文摘要: 目的 探讨区域麻醉或镇痛（RA）能否改善肿瘤切除术后患者的预后。方法 基于PubMed、Cochrane、Embase和Medline数据库检索RA与癌症术后患者预后相关的研究，提取相关数据后，用 HR 和95% CI 分析单独RA或RA联合全身麻醉（GA）与单独GA对患者预后的影响。结果 共有62项研究纳入Meta分析，结果显示RA可以改善肿瘤患者术后总生存率（OS）（ HR =0.90，95% CI ：0.84～0.96，P=0.001）和无进展生存率（PFS）（ HR =0.50，95% CI ：0.31～0.80，P=0.004）；RA与无复发生存率（RFS）、生化无复发生存率（BRFS）、癌症复发率（RR）或癌症特异性生存率（CSS）无显著关联（P>0.05）。结论 RA与癌症相关的OS、PFS有关。
Abstract:ObjectiveTo investigate whether regional anesthesia or analgesia (RA) can improve the prognosis of patients after cancer surgery. Methods Based on PubMed, Cochrane, Embase and Medline databases, studies on the relationshiPbetween RA and the prognosis of patients after cancer surgery wassearched. After extracting relevant data, HR and 95% CI were used to analyze the effect of RA and general anesthesia (GA) alone on the prognosis of patients. Results A total of 62 studies were included in the meta-analysis, and the results showed that RA improve postoperative overall survival (OS)( HR =0.90, 95% CI : 0.84-0.96, P=0.001) and progression-free survival (PFS)（ HR =0.50，95% CI ：0.31-0.80，P=0.004）of cancer patients; RA was not significantly associated with recurrence free survival (RFS), biochemical recurrence free survival (BRFS), cancer recurrence rate (RR) and cancer specific survival (CSS) (P>0.05). Conclusion RA is associated with cancer-related OS and PFS.
keywords: Regional anesthesia, analgesia Nerve block Cancer Prognosis Overall survival Progression-free survival Meta-analysis
文章编号： 中图分类号： 文献标志码：A
基金项目:南京市科技计划项目（201803068）
| Author Name | Affiliation |
| SONG Xin-ting, YIN Ning | Department of Anesthesiology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, China |
| Author Name | Affiliation |
| SONG Xin-ting, YIN Ning | Department of Anesthesiology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, China |
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