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Received:December 08, 2021 Published Online:May 20, 2022
Received:December 08, 2021 Published Online:May 20, 2022
中文摘要: 目的 系统评价肺癌患者术后静脉血栓栓塞发生的情况和特点,为开展肺癌患者术后相关预防与控制工作提供科学依据。方法 计算机检索中国知网、维普、中国生物医学文献数据库、万方、PubMed、Embase和Web of Science数据库,搜集关于中国肺癌患者术后静脉血栓发生率的横断面研究,检索时限均从建库至2021年10月。采用Stata 15.1软件进行Meta分析。结果 最终纳入11篇文献,共计2 862例肺癌术后患者,其中326例患者发生肺静脉血栓栓塞。Meta分析结果显示,肺癌术后静脉血栓栓塞发生率为16.0%(95% CI :0.12~0.20)。亚组分析显示中国肺癌术后静脉血栓栓塞发生率在有/无吸烟史(20%/10%)、有/无高血压史(23%/10%)、有/无冠心病史(21%/11%)、有/无糖尿病史(19%/13%)、老年/中青年(24%/14%)中差异有统计学意义(P<0.01)。结论 中国肺癌术后患者静脉血栓栓塞发生率较高,有吸烟史、高血压史、冠心病史、糖尿病史肺癌术后静脉血栓栓塞发生率更高。
Abstract:ObjectiveTo systematically evaluate the occurrence and characteristics of postoperative venous thromboembolism (VTE) in patients with lung cancer, and to provide a scientific basis for the relevant postoperative prevention and control of lung cancer patients. Methods The CNKI, VIP, SinoMed, WanFang, PubMed, Embase, and Web of Science databases were searched for cross-sectional studies on the incidence of postoperative VTE in Chinese lung cancer patients, and the retrieval time limit ranged from library establishment to October 2021. Meta-analysis was conducted by Stata 15.1 software. Results Finally, 11 articles were included, involving a total of 2 862 patients with lung cancer after surgery, of which 326 patients developed pulmonary VTE. The results of the Meta-analysis showed that the postoperative VTE incidence of lung cancer was 16.0% (95% CI :0.12-0.20). SubgrouPanalysis showed that the incidence of VTE after lung cancer surgery in China was significantly different in patients with/without smoking history (20%/10%), with/without history of hypertension (23%/10%), with/without history of coronary heart disease (21%/11%), with/without diabetes history (19%/13%), elderly/young and middle-aged (24%/14%) (P<0.01). Conclusion The incidence of VTE in Chinese patients after lung cancer surgery is higher, and the incidence of VTE after lung cancer surgery is higher with a history of smoking, hypertension, coronary heart disease, and diabetes.
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基金项目:国家重点研发计划专项(2018YFC1311900)
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