Abstract:Objective To observe the analgesic effects and adverse reactions of auricular point pressing needle in invitro fertilization-embryo transfer(IVF-ET)transvaginal ultrasound-guided oocyte retrieval(TVOR), and to explore its possible analgesic mechanism. Methods From January 2020 to February 2021, 210 patients received IVF-ET TVOR were divided into 3 groups according to treatment： press needle group, auricular point press group, and drug control group, with 70 cases in each group. The selected auricular point in press needle group and auricular point press group were bilateral uterus, pelvic cavity, Shenmen, sympathetic, subcortical, and endocrine. The drug control group was given indomethacin 0.1 g sodium anus. The pain grading index (PRI), current pain intensity (PPI), visual analogue grading method (VAS) during and 1 hour after the TVOR, the incidence of intraoperative and postoperative adverse reactions, TVOR operation time and number of oocytes obtained were compared among three groups. Results There was no significant difference in the TVOR operation time and number of oocytes obtained in three groups (P>0.05). The PRI, VAS, and PPI scores of the press needle group, auricular point press group, and drug control group showed a tendency to increase during the operation and 1 h after the operation, and the difference was significant (P＜0.05). The incidence of total adverse reactions in the press needle group (8.57%) and auricular point press group (10.00%) was lower than that of the drug control group (34.29%), and the difference was significant (P＜0.01). Conclusion The analgesic effect of auricular point pressing needle in IVF-ET TVOR is better, the incidence of intraoperative and postoperative adverse reactions is low, and the effect is better than auricular point press bean.