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Received:June 26, 2021 Published Online:February 20, 2022
Received:June 26, 2021 Published Online:February 20, 2022
中文摘要: 目的 研究单核细胞/高密度脂蛋白胆固醇比值(MHR)与白塞病疾病活动性的相关性,进一步探讨其作为评估白塞病活动性的潜在标志物的可能性。方法 选取2019年1月至2020年12月青海大学附属医院风湿免疫科白塞病初治住院患者43例为病例组,体检中心43例健康者为对照组,根据电子病历疾病活动性指数(EMRAI)将病例组分为高活动性组和低活动性组,比较病例组和对照组的C反应蛋白(CRP)、红细胞沉降率(ESR)和MHR水平,分析MHR与CRP、ESR的相关性,采用ROC曲线分析MHR对白塞病疾病活动性度的判断效能。结果 病例组的CRP、ESR及MHR水平均显著高于对照组,差异有统计学意义(P<0.01)。高疾病活动性组的MHR水平高于低疾病活动性组[(0.64±0.28)×109/mmol vs (0.36±0.20)×109/mmol,P<0.01]。Spearman相关分析表明,MHR与EMRAI、ESR、CRP分别呈正相关关系(r=0.504、0.311、0.555,P<0.01)。ROC曲线分析显示,MHR区分低疾病活动性与高疾病活动性白塞病患者的最佳临界值为0.317×109/mmol,ROC曲线下面积为0.798[95%CI(0.660~0.941),P<0.01]。结论 MHR与EMRAI呈正相关性,MHR对白塞病患者疾病活动度有较高判断效能,提示其或可作为白塞病活动性评估的生物学标志物。
中文关键词: 白塞病 单核细胞/高密度脂蛋白胆固醇 电子病历疾病活动性指数 C反应蛋白 红细胞沉降率
Abstract:Objective To analyze the relationship between monocyte/high-density lipoprotein cholesterol ratio (MHR) and Behcet's disease(BD) activity, to further explore its possibility as a potential marker for evaluating disease activity in BD. Methods Forty-three BD inpatients in the Qinghai University Affiliated Hospital from January 2019 to December 2020 were selected as case group, and 43 healthy persons were served as control group. The patients in case group was divided into high-activity group and low-activity group according to electronic medical record-based disease activity index (EMRAI). The C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and MHR level were compared between two groups, the associations of MHR with CRP and ESR was analyzed. The judgment efficiency of MHR on BD activity was analyzed by drawing receiver operating characteristics (ROC) curve. Results The levels of CRP, ESR and MHR in case group were significantly higher than those in control group (P<0.01), and MHR in high-activity group was higher than that in low-activity group[(0.64±0.28)×109/mmol vs (0.36±0.20)×109/mmol,P<0.01]. Spearman correlation analysis showed that MHR was positively correlated with EMRAI, ESR and CRP respectively (r=0.504, 0.311,0.555,P<0.01). ROC analysis showed that the optimal critical value of MHR in distinguishing between low disease activity and high disease activity in BD patients was 0.317×109/mmol, and the area under ROC was 0.798 [95%CI(0.660-0.941), P<0.01] . Conclusion MHR is positively correlated with EMRAI and has a higher judgment efficiency on disease activity in BD patients, suggesting that it may be used as a biomarker for the evaluation of Behcet's disease activity.
keywords: Behcet's disease Monocyte to high-density lipoprotein cholesterol ratio Electronic medical record-based disease activity index C-reactive protein Erythrocyte sedimentation rate
文章编号: 中图分类号:R593.22 文献标志码:A
基金项目:青海省科技厅应用基础研究科技计划项目(2019-ZJ-7094)
Author Name | Affiliation |
YAN Li-fang, CHAI Ke-xia | Department of Rheumatism and Immunology, Qinghai University Affiliated Hospital, Xining, Qinghai 810000, China |
Author Name | Affiliation |
YAN Li-fang, CHAI Ke-xia | Department of Rheumatism and Immunology, Qinghai University Affiliated Hospital, Xining, Qinghai 810000, China |
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