Abstract:Objective To investigate the clinical value of preoperative peripheral blood neutrophil/lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), CA125, vascular tumor thrombus， myometrial invasion in endometrial carcinoma patients undergoing lymph node dissection to provide more accurate diagnosis and treatment. Methods The clinicopathological data of 102 patients with endometrial carcinoma treated in the Affiliated Hospital of Weifang Medical College from April 2019 to April 2021 were collected. The detections of blood routine, CA125 and MRI were conducted in all patients before operation, and carbon nanoparticles suspension injection (2 ml) was injected into the cervix 5 minutes before operation. The laparoscopic surgery with SLN resection and systematic lymph node dissection was performed. Multivariate Logistic regression analysis was used to screen the high-risk factors of SLN metastasis, and ROC curve analysis was performed. Results There were 22 cases of SLN positive (21.6%) and 80 cases of SLN negative (78.4%). Multivariate Logistic regression analysis showed that CA125 level≥35 μ/ml (P=0.016,OR=4.873,95%CI：1.352-17.570)，vascular tumor thrombus(P=0.004,OR=7.891,95%CI ：1.956-31.832), myometrial invasion≥1/2 (P=0.003,OR=13.714,95%CI： 2.410-78.034) were the independent influencing factors of SLN metastasis. ROC curve analysis showed that the AUC achieved by combined prediction of the three factors was 0.892. Conclusion Preoperative CA125 level combined with vascular tumor thrombus， myometrial invasion has high sensitive and accurate in prediction of sentinel lymph node metastasis.