Abstract:Objective To investigate the correlation between serum carbohydrate antigen(CA)19-9 and visceral fat area (VFA) in the patients with type 2 diabetes mellitus (T2DM). Methods A total of 312 T2DM patients who received treatment at Affiliated Hospital of Southwest Medical University from July 2014 to May 2019 were selected and divided into CA19-9≤30 u/ml group (n=236)and CA19-9>30 u/ml group (n=76).The following indicators were measured and analyzed in two groups,including gender,age,fasting blood glucose,diastolic blood pressure(DBP),systolic blood pressure(SBP),height,weight,BMI,head,neck,waist and hip circumference,VFA,subcutaneous fat area(SFA),history of hypertension,hyperlipidemia history,smoking history,drinking history,fasting C-peptide,120-minute C-peptide values,levels of HbA1c,ALT,AST,alkaline phosphatase(ALP),gamma glutamyltransferase (γ-GT),blood urea nitrogen(BUN),uric acid(UA),creatinine (CR),TG,TC,HDL-C,LDL-C,hsCRP,CEA,CA19-9 and other related indicators. Results Logistic regression analysis showed that BMI,blood glucose,and VFA were independent influencing factors of elevated CA19-9 (P<0.05).The VFA was positively correlated with CA19-9 (P<0.05). Conclusion T2DM patients with higher blood glucose and VFA levels can be accompanied by higher serum CA19-9 levels.