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Received:June 07, 2020 Published Online:February 20, 2021
Received:June 07, 2020 Published Online:February 20, 2021
中文摘要: 目的 探讨超声成像对原发性干燥综合征(PSS)患者唾液腺硬度的评价效能。方法 回顾性选择2018年3月至2019年11月收治的74例PSS患者的临床资料作为PSS组,同期选择68例健康体检者作为对照组。对所有研究对象的腮腺和颌下腺进行声触诊组织定量(VTQ)和声触诊组织成像与定量(VTIQ)检查,比较两组VTQ和VTIQ评分值、腮腺和颌下腺大小。比较PSS患者VTQ和VTIQ评分值及腮腺和颌下腺的超声诊断敏感度、特异度和约登指数。结果 两组腮腺长度和宽度比较差异无统计学意义(P>0.05)。PSS组颌下腺长度［(28.30±3.10)mm vs (35.00±3.80)mm］和宽度［(11.10±2.40)mm vs (15.40±1.50)mm］均显著小于对照组(P<0.01)。PSS组双侧腮腺和双侧颌下腺的超声评分以及所有腺体的总评分显著高于对照组(P<0.05，P<0.01)。颌下腺超声诊断PSS的特异度(90.37% vs 82.54%)、敏感度(93.25% vs 75.57%)、约登指数(83.62% vs 53.11%)均高于腮腺(P<0.05)。PSS组腮腺VTQ值、VTIQ值和颌下腺VTIQ值显著高于对照组(P<0.01);而两组颌下腺VTQ值差异无统计学意义(P>0.05)。PSS组颌下腺VTIQ值显著高于VTQ值(P<0.01)。PSS患者腮腺VTQ和VTIQ呈正相关关系(r=0.870,P<0.01),颌下腺VTQ和VTIQ呈正相关关系(r=0.530,P<0.01)。结论 PSS患者大唾液腺硬度显著高于健康人群,能够通过超声VTQ和VTIQ成像加以区分,超声在诊断PSS方面具有一定临床应用价值。
中文关键词: 干燥综合征 超声影像 唾液腺硬度 声触诊组织成像与定量 声触诊组织定量
Abstract:Objective To explore the diagnostic performance of ultrasound imaging in evaluating salivary gland stiffness in patients with primary Sjogren′s syndrome (PSS).Methods A retrospective analysis was performed on the clinical data of 74 PSS patients from March 2018 to November 2019 (PSS group),and 68 healthy persons were served as control group during the same period.Using virtual touch tissue quantification(VTQ）and virtual touch tissue imaging quantification(VTIQ）for all subjects,the scores of VTQ and VTIQ and the sizes of parotid and submandibular gland were compared between two groups to analyze the differences in VTQ and VTIQ and in sensitivity,specificity and Youden′s index in ultrasound diagnosis of parotid and submandibular glands.Results There were no significant differences in the length and the width of parotid gland between PSS group and control group ( P>0.05).The length ［(28.30±3.10)mm vs (35.00±3.80)mm］ and width ［(11.10±2.40)mm vs (15.40±1.50)mm］ of the submandibular gland in PSS group were significantly smaller than those in control group ( P<0.01).The average scores of ultrasound for bilateral parotid glands and submandibular glands in PSS group were significantly higher than those in control group ( P<0.05, P<0.01).In terms of the diagnostic efficacy of ultrasound testing,the specificity (90.37% vs 82.54%),sensitivity (93.25% vs 75.57%) and Youden′s index(83.62% vs 53.11%) in submandibular gland were statistically higher than those in parotid gland in PSS group ( P<0.05).The values of VTQ and VTIQ of parotid gland and VTIQ value of submandibular gland in PSS group were significantly higher than those in control group ( P<0.01),but there was no significant difference in VTQ value of submandibular gland between two groups( P>0.05).In PSS group,VTIQ value of submandibular gland was significantly higher than that in control group ( P<0.01),and there were positive correlations between VTQ and VTIQ in parotid gland ( r=0.870, P<0.01) and in submandibular gland（ r=0.530, P<0.01）.Conclusion Salivary glands stiffness in PSS patients is significantly higher than that in normal people and can be distinguished by VTQ and VTIQ.Ultrasound provides a certain clinical application value in the diagnosis of PSS.
keywords: Primary Sjogren′s syndrome Ultrasound imaging Salivary gland stiffness Virtual touch tissue imaging quantification Virtual touch tissue quantification
文章编号： 中图分类号：R593.2 文献标志码：B
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