Abstract:Objective To compare the application effects and prognosis of standard operation(total thyroidectomy with central lymph node dissection) and non-standard operation in the patients with sporadic medullary thyroid carcinoma（MTC）.Methods Eighty-seven patients with sporadic MTC admitted to hospital from January 2013 to June 2014 were selected as the research objects and divided into control group ( n=42) and observation group ( n=45) according to operation mode.Non-standardized surgery was performed in control group,and standardized surgery was conducted in observation group.The clinical effect and prognosis were compared after operation between two groups.Results After treatment,the levels of calcitonin and carcinoembryonic antigen(CEA) significantly decreased in two groups compared with those before surgery and were significantly lower in observation group than those in control group （ P<0.01）.There was no significant difference in the incidence of postoperative complications between observation group and control group (6.67% vs 7.14%, χ2=0.113, P>0.05).The 5-year biochemical cure rate in control group was significantly lower than that in observation group (69.05% vs 97.78%, χ2=13.280, P<0.01),and the 5-year recurrence rate was significantly higher than that in observation group (30.95% vs 2.22%, χ2=13.280, P<0.01).Conclusion For the patients with sporadic MTC,standardized surgical treatment can reduce the serum calcitonin and CEA levels and the recurrence rate,increase the 5-year biochemical cure rate without increasing postoperative complications.