Abstract:Objective To investigate the clinical characteristics,diagnosis,treatment and outcome of cerebral venous sinus thrombosis (CVST) in first trimester pregnancy. Methods A retrospective analysis was performed on the data of patients with CVST during the perinatal period admitted to Xuanwu Hospital of Capital Medical University from December 2015 to December 2019. Results There were 39 cases of perinatal CVST,including 11 cases in first trimester pregnancy (28.21%).Among the 11 cases of CVST in early pregnancy,there were 3 primiparas and 8 multiparas with 22-42 years old.Headache (10 cases),epilepsy (5 cases),disturbance of consciousness (3 cases) and limb weakness (5 cases) were the most common clinical manifestations.Magnetic resonance imaging revealed superior sagittal sinus thrombosis in 8 cases,transverse sinus in 9 cases,sigmoid sinus in 9 cases and multiple venous sinuses thrombosis in the majority of patients (10 cases).Low molecular weight heparin sodium anticoagulant therapy was the first choice for the patients,with 8 patients receiving effective anticoagulant therapy alone and 3 patients requiring interventional therapy;there were 2 cases of full-term delivery and 9 cases of choosing to terminate pregnancy;10 cases were cured,and 1 case had residual left limb dysfunction. Conclusion CVST in first trimester pregnancy is a rare cerebrovascular disease with no specific clinical manifestations,but a good clinical outcome can be obtained if it is found,diagnosed and treated early.