Abstract:Objective To investigate the clinical effect of Yishen Jianpi decoction on tumor related asthenia of spleen and kidney deficiency syndrome.Methods A total of 60 patients with tumor related fatigue admitted from October 2018 to March 2019 were divided into experimental group and control group randomly ( n=30,each).The experimental group was treated with Yishen Jianpi decoction,while the control group was treated with nutritional support.All the patients received treatment for 2 weeks.The improvement of fatigue (BFI-C),sleep (PSQI),depression (HADS) and Traditional Chinese Medicine(TCM) symptom score were observed and compared between the two groups.Results The effective rate of fatigue treatment in the experimental group was higher than that in the control group (48.28% vs 10.34%, χ2=8.290, P=0.004).The total effective rate of TCM syndrome in the experimental group was higher than that in the control group (65.51% vs 31.03%, χ2=6.905, P=0.009).After 2 weeks of treatment,the BFI-C score of the experimental group was improved compared with that before treatment,and the BFI-C score of the experimental group was lower than that of the control group ( P<0.05).There was no significant difference in grip strength,depression and sleep quality between the two groups before and after treatment ( P>0.05).Conclusion Yishen Jianpi decoction has a certain effect on tumor related asthenia.