Abstract:Objective To investigate the clinical effect of Bushen Huoxue decoction on diabetic osteoporosis (DOP).Methods A total of 55 outpatients or inpatients with DOP who received treatment in the Department of TCM or Endocrinology from January 2017 to January 2020 were randomly divided into control group ( n=27) and treatment group ( n=28).The control group was treated with calcium carbonate and vitamin D3 tablets 600 mg+calcitriol capsules 0.5 μg on the basis of controlling other primary diseases,and the treatment group was added with Bushen Huoxue decoction on the basis of control group.The treatment period was 6 months.The VAS score,liver function ［alanine aminotransferase (ALT),glutamate aminotransferase (AST)］,bone metabolism index ［type I collagen N-terminal lengthening peptide (P1NP),β-I collagen carboxyl terminal peptide (β-CTX)］,bone mineral density (BMD) were observed and compared between the two groups before and after treatment.Results Compared with the control group,the VAS score and β-CTX level in the treatment group were decreased,the P1NP level,BMD of lumbar spine (L1-4) and left femur was increased ( P<0.05).There was no significant difference in liver function between the two groups before and after treatment ( P>0.05).Conclusion Bushen Huoxue decoction could relieve pain,improve bone metabolism and increase bone mineral density in patients with DOP without obvious liver damage,which can be used in clinical treatment of DOP.