Abstract:Objective To observe the clinical effect of Sangbai Shengfa liniment in the treatment of patients with alopecia. Methods Out of 70 patients with alopecia areata and seborrheic alopecia (stasis-heat and microbial turbidity type) from January 2015 to March 2016,60 cases were selected and randomly divided into observation group and control group (n=30,each).Sangbai Shengfa liniment(National Invention Patent:LZ200810196315.2，refined by the pharmaceutical factory of Nanjing University of traditional Chinese Medicine) was used in observation group,and 2% minoxidil tincture topical was used in control group.The comprehensive treatment effect was observed and compared between two groups after treatment of 6 months. Results There was no statistical difference in the total effective rate between two groups(86.67% vs 80.00%,P>0.05).In observation group,the levels of CD3⁺,CD4⁺/CD8⁺showed an increasing trend,but there were no significant differences in them (P=0.106,P=0.104) and in the levels of CD4⁺,CD8⁺,CD19⁺and CD16⁺/CD56⁺compared with those before treatment (all P>0.05).In control group,only CD3⁺level was higher than that before treatment (P=0.037),and CD4⁺/CD8⁺showed an increasing trend (P=0.052).After treatment,the level of CD4⁺ in observation group was statistically higher than that in control group (P=0.010),and there were no significant differences in other items between two groups (all P>0.05). Conclusion In the treatment of alopecia areata and seborrheic alopecia (stasis-heat and microbial turbidity type),both Sangbai Shengfa liniment and minoxidil tincture present the similar clinical effect and have no significant impacts on the immune indexes,and no obvious toxic and side effects.