Abstract:Objective To investigate the short-term efficacy and prognostic factors of apatinib combined with chemo-radiotherapy in the treatment of recurrent cervical cancer with metastasis. Methods A total of 98 patients with postoperative recurrence and metastasis of cervical cancer who received treatment from October 2011 to October 2016 were selected as study objects.The clinical data of patients were analyzed retrospectively.According to the treatment plan,they were divided into combination group and control group (n=49,each).The control group patients received conventional chemotherapy and radiotherapy,and the combined group patients received apatinib in combination on the basis of the control group.The short-term efficacy and side effects were compared between the two groups.Univariate analysis and multivariate Cox regression analysis were used to analyze the prognostic factors of recurrent cervical cancer patients with metastasis. Results One month after the end of treatment,the evaluation was conducted.The clinical total effective rate of the combined group was significantly higher than that of the control group (93.88% vs 77.55%,P<0.05).Liver function injury,gastrointestinal reaction,radiation cystitis,radiation proctitis and bone marrow suppression occurred in both groups,but there was no significant difference between the two groups (all P>0.05).The follow-up time of all patients was 2-36 months.The 3-year survival rate of all patients was 53.06% (52/98).The 3-year survival rate of the control group was 44.90% (22/49) and that of the combination group was 61.22% (30/49).Univariate analysis showed that tumor diameter,number of lymph node metastasis,intravascular tumor and clinical stage were related to the prognosis of patients with recurrent and metastatic cervical cancer (P<0.05,P<0.01).Multivarate stepwise Cox proportional hazard regression analysis showed that combination therapy was a good prognostic factor for patients with recurrent and metastatic cervical cancer (P<0.05).Clinical stage IV,number of lymphatic metastasis >3 and presence of intrarascular tumor were independent risk factors for the prognosis of patients with recurrent and metastatic cervical cancer (P<0.05,P<0.01). ConclusionsIn the treatment of recurrent cervical cancer with metastasis,apatinib combined with chemo-radiotherapy could improve the short-term efficacy of patients.The prognosis of patients with recurrent and metastatic cervical cancer may be closely related to the number of lymphatic metastasis,intravascular tumor and clinical stage,so the above factors should be paid attention to in the treatment.