Abstract:Objective To study the status of health literacy and frailty level in elderly osteoporosis patients and the to analyze association between health literacy and frailty. Methods Using convenience sampling method, 191 elderly osteoporosis patients from May 2018 to September 2019 were selected and investigated by health literacy questionnaire (HLQ)and comprehensive frailty assessment instrument(CFAI). Results A total of 200 questionaires were distributed and 191 questionaires were effectively recavered(95.5%).HLQ was 54-119 (94.23±14.81), and CFAI was 30-93(52.76±16.14) in the patients.Different ages, diabetes mellitus, hypertension, degree of self-care ability and depression had significant impacts on the frailty（P＜0.05, P＜0.01）.Pearson correlation analysis showed that the scores of each dimension of health literacy were negatively correlated with those of CFAI (P<0.01).Multiple linear regression analysis showed that basic health care, disease prevention and control, safety and first aid in each dimension of health literacy were the influencing factors of frailty (P<0.01), explaining 25.9% of the variance variation. Conclusion The senile osteoporosis patients are relatively frail with lower health literacy.Health literacy is the influencing factor of reducing frailty, so the clinicians and nurses should pay attention to strengthening the evaluation and intervention of patients′ health literacy.