Abstract:ObjectiveTo study the influences of ligoliptin on blood glucose and cognitive function in elderly patients with type 2 diabetes mellitus (T2MD) complicated with mild cognitive impairment after stroke and its mechanism.MethodsSixty T2MD patients complicated with cognitive dysfunction after stroke were selected and randomly divided into observation group and control group (n=30,each).Ligoliptin was used in observation group,and sulfonylurea was used in control group.The levels of fasting blood glucose (FBG),2-hour postprandial blood glucose (2hPG) and HbA1c were observed before and 6 months after treatment.The cognitive function was evaluated by Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MoCA) and compared between two groups.Plasma amyloid β protein 1-40 (Aβ1-40) and Aβ1-42 levels and serum levels of inflammatory factors such as C-reactive protein (CRP),tumor necrosis factor (TNF)-α,interleukin (IL)-6 were measured and compared between two groups.ResultsAfter treatment,the levels of FBG,2hPG and HbA1c were statistically lower than those before treatment in two groups (P<0.05),however,there were no significant differences in them between two groups before and after treatment (P>0.05);MMSE and MOCA scores in observation group were higher than those before treatment and higher than those in control group (P<0.01);Aβ1-42/Aβ1-40 ratio was significantly higher than that before treatment in two groups and was higher in observation group than that in control group (P<0.01);the levels of CRP,TNF-α and IL-6 were statistically lower than those before treatment in two groups and were statistically lower in observation group than those in control group (P<0.05,P<0.01).ConclusionIn the treatment for elderly T2MD patients with mild cognitive impairment after stroke,liggliptin can reduce blood glucose and improve cognition,the mechanism of which may be related to the improvement of Aβ aggregation and the reduction of inflammatory response in vivo.