Abstract:ObjectiveTo compare the effects of off-pump coronary artery bypass grafting(OPCABG) and routine on-pump CABG(ONCABG) on three-vessel coronary heart disease with stenosis patients.MethodsEighty patients with coronary artery stenosis receiving CABG from March 2016 to March 2018 were enrolled in a retrospective study and divided into observation group (OPCABG group,n=35) and control group (ONCABG group,n=45).The short-term indicators including operation time,ICU retention time,mean blood flow velocities (MF),pulsation index (PI),plasma B-type natriuretic peptide (BNP),CRP levels and incidence of complications within 30 days were observed.The follow-up time ranged from 15 to 36 months,with an average of 25 months in two groups.Long-term indicators including overall survival rate,cardiac-related mortality,patency rate of bridging vessels and revascularization rate were observed and compared between two groups.ResultsCompared with control group,MF values of arterial and venous bridges increased,the operation time and ICU retention time,PI value,levels of plasma BNP and CRP and incidence of complications decreased in observation group （P＜0.05,P<0.01）.There were no significant differences in overall survival rate and cardiac-related mortality rate during follow-up between two groups (P＞0.05).However,the patency rate of bridge blood vessels in observation group was statistically higher than that in control group,and the revascularization rate was lower than that in control group（P＜0.05）.ConclusionsCompared with ONCABG,OPCABG has less interference on the circulation of the body and quicker recovery for patients after operation.In the patients with complex three-vessel coronary stenosis heart disease,OPCABG has more advantages in increasing blood flow of bridging vessels,reducing perioperative stress and inflammatory reaction,short-term complications and long-term mortality,improving survival rate and patency rate of bridging vessels and decreasing secondary operation risk.