Abstract:Objective To investigate the clinical efficacy of neostigmine combined with electrical stimulation on functional recovery and improvement of pelvic floor muscle contractility in patients with postpartum pelvic floor dysfunction. Methods A total of 130 patients with postpartum pelvic dysfunction disease treated from January 2017 to January 2019 were selected and randomly divided into control group and observation group(n=65,each ).Electrical stimulation therapy was performed in control group,and neostigmine was added based on electrical stimulation therapy in observation group.After 6 weeks of treatment,the clinical efficacy,functional recovery,pelvic floor muscle contractility,sexual function and adverse reactions were compared between two groups. Results The total effective rate in observation group was significantly higher than that in control group (86.15% vs 70.77%,χ²=4.552,P<0.05).After treatment,the fatigue degree and the percentage of vaginal resistance significantly increased in two groups and were higher in observation group than those in control group (all P<0.01);the scores of class Ⅰ and Ⅱ pelvic floor muscle strength and quality of life were significantly higher than those before treatment in both groups,and were statistically higher in observation group than those in control group (all P<0.01).There was no significant difference in the incidence of adverse reactions between observation group and control group (4.62% vs 0,χ²=1.365,P=0.243). Conclusion For the patients with postpartum pelvic floor dysfunction,neostigmine combined with electrical stimulation can significantly increase the treatment efficiency,relieve pelvic floor muscle fatigue,restore vaginal resistance,improve pelvic floor muscle strength and the patients′ sexual life without increasing the incidence of adverse reactions compared with electrical stimulation alone.