Abstract:Objective To investigate the expression of serum β cross-linked C-telopeptide of typeⅠcollagen (β-CTX),osteocalcin (OC),type I procollagen N-terminal propeptide (PINP),and 25-hydroxyvitamin D₃ ［25(OH)D₃］in elderly patients with type 2 diabetes (T2DM) and their correlation with blood glucose and insulin levels. Methods From May 2017 to December 2019,120 elderly T2DM patients were selected as the T2DM group,and 86 healthy people during the same period were selected as the healthy group. The levels of serum β-CTX,OC,PINP,25(OH)D₃, and blood glucose and insulin indexes were measured and compared between the two groups. Pearson analysis was used to analyze the correlation between serum β-CTX,OC,PINP,25(OH)D₃ expression and blood glucose and insulin indexes in elderly T2DM patients.Multiple linear regression was used to analyze the related factors affecting blood glucose and insulin indexes. Results The levels of serum β-CTX and PINP in the T2DM group were higher than those in the healthy group,and the levels of serum OC and 25(OH)D₃ were lower than those in the healthy group,while the levels of 2 hPG,FPG,FINS and HOMA-IR in T2DM group were higher than those in healthy group (all P<0.05).Serum β-CTX and PINP levels were positively correlated with 2 hPG,FPG,FINS,and HOMA-IR levels in elderly T2DM patients,and serum OC,25(OH)D₃ levels were negatively correlated with 2 hPG,FPG,FINS,and HOMA-IR levels (all P<0.01).Serum β-CTX,OC,PINP,and 25(OH)D₃ were all important factors influencing blood glucose and insulin indexes (all P<0.01). Conclusion Serum β-CTX,OC,PINP,and 25(OH)D₃ expression in elderly T2DM patients are significantly abnormal,and are significantly correlated with blood glucose and insulin indicators.