Abstract:Objective To study the correlation between small dense low-density lipoprotein (sd-LDL) and cardiovascular and cerebrovascular diseases.The aim is to provide new ideas for early diagnosis and treatment of cardiovascular and cerebrovascular diseases. Methods A total of 104 patients with cardiovascular and cerebrovascular diseases admitted from the department of cardiology and brain surgery from January to August 2019 were selected as study objects,including 11 patients with cerebral hemorrhage,75 patients with cerebral infarction and 18 patients with coronary heart disease(CHD).In the same period,50 healthy individuals were served as the normal control group.Biochemical indexes of each group were compared (including TG,TC,LDL-C,HDL-C,sd-LDL-C),and correlation analysis was conducted. Results The sd-LDL-C levels in cerebral hemorrhage group were higher than that in normal control group;TG and sd-LDL-C levels in cerebral infarction group were higher than those in normal control group,and LDL-C was lower than that in normal control group;the TG,sd-LDL-C levels in CHD group were higher than those in normal control group(all P<0.05).Pearson linear correlation analysis showed that sd-LDL-C was positively correlated with TG and sd-LDL-C in patients with cerebral hemorrhage and CHD,respctively(all P<0.05);sd-LDL-C was positively correlated with TG in patients with cerebral infarction (P<0.05).Spearman rank correlation analysis showed that there was a positive correlation between sd-LDL-C and cerebral infarction (r=0.491,P＜0.01). Conclusion There are significantly high levels sd-LDL-C in serum of patients with cerebral hemorrhage,cerebral infarction and CHD,which may play a role in the early diagnosis of the above diseases,and is worthy of clinical attention.