Abstract:Objecitve To investigate the relationship between the quantitative parameters of ultrasound elastography(UE) and the expressions of matrix metalloproteinase-9 (MMP-9), angiopoietin-1 (ANG-1), α-cyano-(3, 4-hydroxy) n-benzylstyrene amine (AG490), wild-type p53-induced phosphatase-1(WIP1) in patients with thyroid carcinoma. Methods A total of 120 patients with thyroid carcinoma treated from June 2017 to June 2019 were selected as observation group, and 98 patients with benign thyroid nodules were served as control group in the same period.All patients underwent UE examination and gene detection of focus tissue.The expression levels of MMP-9, ANG-1, AG490 and WIP1 in focus tissues were compared between two groups.Logistic regression analysis was used to explore the influencing factors of thyroid carcinoma, and the ratio of shear wave velocity(Vs) and the expression levels of MMP-9, ANG-1, AG490 and WIP1 in the patients with different Vs ratio were compared between two groups.The relationships between quantitative parameters of UE and the expressions of MMP-9, ANG-1, AG490 and WIP1 were analyzed by Pearson correlation. Results The expression levels of MMP-9, ANG-1 and WIP1 in observation group were significantly higher than those in control group, and the expression level of AG490 was lower than that in control group (P<0.05).Logistic regression analysis showed that MMP-9, ANG-1 and WIP1 were the important risk factors of thyroid cancer, and AG490 was the protective factor (P<0.05).In the patients with Vs ratio more than 3.14, the expression levels of MMP-9, ANG-1 and WIP1 increased, and AG490 decreased significantly compared with those in patients with Vs ratio lower than 3.14 (P<0.05).Pearson correlation analysis indicated that the quantitative parameters of UE were positively correlated with the expression levels of MMP-9 (r=0.569), ANG-1 (r=0.374) and WIP1 (r=0.414) and was negatively correlated with the expression level of AG490 (r=-0.675) significantly (P<0.05). Conclusion In the patients with thyroid carcinoma, Vs ratio is abnormally elevated and is positively correlated with the levels of MMP-9, ANG-1 and WIP1 and negatively correlated with AG490 level, which can provide reliable reference for clinical evaluation of the biological behavior of the focus tissue and formulation of targeted treatment plan.