Abstract:Objecitve To explore the predictive value of preoperative MRI multi-sign analysis on the outcome of breast cancer after neoadjuvant chemotherapy (NAC) and the impacts on the recurrence of patients after NAC. Methods A retrospective analysis was made on the clinical data of 76 breast cancer patients treated with NAC from June 2012 to June 2015.According to pathological response assessment by Miller-Payne grading system, the patients were divided into pathological complete remission (PCR) group and incomplete remission (NPCR) group.The differences of clinicopathological data and preoperative MRI data were compared between PCR group and NPCR group, and the independent predictors of NAC outcome were analyzed by multivariate logistic regression.With following up in a cohort of the patients and establishment of Cox proportional hazards regression model, single-factor and multi-factor analysis were performed to analyze the influence factors of the early recurrence (36 months) of breast cancer. Results After NAC, there were 21 cases of PCR and 55 cases of NPCR.Single factor analysis showed that there were significant differences in Ki-67, molecular subtypes of breast cancer, peritumoral edema and ring enhancement on MRI between two groups (P<0.01).Logistic regression analysis showed that molecular subtypes (OR =3.294, P=0.035), peritumoral edema (OR =8.939, P=0.016), ring enhancement (OR =13.333, P=0.012) were the independent predictors of PCR in breast cancer patients after NAC.Cox multivariate analysis showed that peritumoral edema (HR=6.796, P<0.01) was a risk factor for postoperative recurrence of breast cancer, and PCR after NAC was the protective factor for breast cancer (HR=0.036, P<0.001). Conclusion Preoperative MRI is of great value in predicting PCR and early recurrence of breast cancer patients after NAC.