Abstract:Objective To study the effects of highly active antiretroviral therapy (HAART)in the treatment of acquired immunodeficiency syndrome(AIDS) and its influence on the immune function of the patients. Methods Sixty AIDS patients from January 2015 to January 2017 were treated with HAART,that is,with three or more medications including lamivudine⁺zidovudine/tenofovir⁺nevirapine/efavirenz.After treatment,the patients were followed up by outpatient revisit or telephone for more than one year.The viral load of HIV-1 and CD4⁺T lymphocyte counts were measured respectively before treatment,6-month and 12-month after treatment.The quality of life of the patients before and after treatment was evaluated by the Short -Form 36 Health Survey Scale（SF-36）,and the incidence of adverse reactions was observed. Results During one-year follow-up period,the mortality rate was 18.33% (11/60),and the survival rate was 81.67% (49/60).Compared with those before treatment,HIV-1 viral load decreased step by step(P<0.01),as well as CD4⁺T lymphocyte count,and SF-36 physical health PCS score,mental health MCS score and SF-36 total score increased step by step at 6-,and 12- month after treatment(all P<0.01),the difference was statistically significant.There was no significant difference in the adverse reaction rate between 12-month and 6-month after treatment (26.53% vs 16.07%),even though it was slightly higher at 12-month after treatment (P>0.05). ConclusionIn the treatment of AIDS,HAART can effectively reduce the HIV-1 viral load of patients and improve the immune function and quality of life of patients.