Abstract:Objective To explore the clinical effect of repairing large area of skin and soft tissue defect of hand with free anterolateral thigh bilobed flaps with a single-perforator nutrition. Methods Twenty-one patients with large-area skin and soft tissue defects of the hand treated from March 2014 to March 2017 were selected as the research objects. The combined bilobate flap (Kiss) with single perforator-based anterolateral thigh flap were transplanted for repairing skin and soft tissue defect of hand, and the therapeutic effect was evaluated by Total Active Motion (TAM) score. Results TAM score demonstrated that the recovery was excellent in 14 cases, good in 6 cases, fair in 0 case and poor in 1 case with an excellent and good rate of 95.23%. For the satisfaction with skin flap appearance, texture and sensory function, 12 cases were satisfied, 6 cases were very satisfied, 0 case was basically satisfied and 3 cases were dissatisfied with satisfaction rate 85.71%. The survival rate of skin flaps was 100% with good color, soft texture and good elasticity. The wounds in the donor and recipient areas healed in one stage, and no vascular crisis occurred. Conclusion The free anterolateral thigh bilobed skin flap with single perforator nutrition has a remarkable effect in repairing large area skin and soft tissue defect of hand, with simple operation and significant recovery.