Abstract:Objective To investigate the prognostic risk factors of endoscopic submucosal dissection for early gastric cancer in the elderly. Methods A total of 149 elderly patients with early gastric cancer who received endoscopic submucosal dissection from January 2015 to January 2018 were selected as the study subjects. The prognosis was evaluated after 12 months of follow-up. Single-factor and multi-factor Logistic regression analysis were used to analyze the risk factors affecting the prognosis of early gastric cancer in the elderly. The investigation factors included gender, tumor diameter, tumor location, pathological type, depth of invasion, smoking history, hypertension, diabetes, body mass index (BMI) and number of positive lymph nodes. Results Among 149 elderly patients with early gastric cancer, 108 (72.48%) had good prognosis and 41 (27.52%) had poor prognosis after endoscopic submucosal dissection. The results of single-factor analysis showed that there was no significant difference in gender, tumor location, pathological type, depth of infiltration, smoking history, hypertension, diabetes and BMI between the two groups (all P>0.05). The tumor diameter and the number of positive lymph nodes in the poor prognosis group were significantly higher than those in the good prognosis group (all P<0.05). The results of multi-factor Logistic regression analysis showed that tumor diameter >2 cm and number of positive lymph nodes ≥6 were the risk factors for the prognosis of elderly patients with early gastric cancer. Conclusion The diameter of tumor and the number of positive lymph nodes are the risk factors for the prognosis of early gastric cancer in the elderly.