Abstract:Objective To investigate the shortterm clinical efficacy and safety of ¹²⁵I seed implantation combined with microwave ablation (MWA) in the treatment of advanced nonsmall cell lung cancer (NSCLC).Methods Eighty NSCLC patients hospitalized from July 2016 to November 2018 were randomly divided into experimental group and control group (n=40,each).The conventional standard chemotherapy was performed in control group,while ¹²⁵I seeds implantation combined with MWA was conducted in experimental group.The clinical efficacy,the improvements of CT value and physical strength and postoperative complications were analyzed in two groups two months after treatment.Results After treatment,CT values were significantly lower than those before treatment in two groups and were significantly lower in experimental group than those in control group (P<0.01);the improvement rate of physical strength (65.0% vs 42.5%,χ2=4.073,P=0.044)and the remission rate（85.0% vs 62.5%,χ2=5.230,P=0.022）in experimental group were significantly higher than those in control group.The incidence of postoperative complications such as pulmonary infection,pleural effusion,chest pain,fever and gastrointestinal reaction in experimental group was statistically lower than those in control group (P<0.05,P<0.01).Conclusion In the treatment for NSCLC patients,¹²⁵I seed implantation combined with MWA has definite clinical effect and can improve the quality of life of patients with fewer complications.