Abstract:Objective To investigate the clinical effect of bixiefenqing pellet in young soldiers with asthenospermia due to kidney-asthenia combined with wetness-evil.? Methods A total of 90 young soldiers with asthenospermia due to kidney-asthenia combined with wetness-evil who received treatment from January 2016 to December 2017 were selected and divided into observation group and control group randomly (n=45, each). The control group patients took vitamin E (100 mg, bid) and levocarnitine (10 mg, bid) orally. The observation group patients took bixiefenqing pellet (6 g, bid), vitamin E (100 mg, bid) and levocarnitine (10 mg, bid) orally. Both group was treated for 12 weeks. Semen routine (sperm motility parameters) were measured by sperm morphology analyzer before and after treatment. Sperm DNA fragmentation index (DFI) was measured by flow cytometry before and after treatment. The improvement of clinical symptoms was evaluated by Chinses Medicine symptom integral before and after treatment. The total effective rate and adverse reactions of the two groups were observed.? Results Compared with control group, the percentages of sperm with progressive motility (grade A + grade B) and sperm with fast progressive motility (grade A) in the observation group were significantly higher[(38.1±11.9) %? vs? (33.0±9.7) %, P<0.05; (18.7±5.5) %? vs? (16.1±4.8) %, P<0.05], and the DFI was significantly higher [(14.8±4.2) %? vs? (17.1±5.1) %, P<0.05], and clinical symptoms score was significantly improved (5.2±1.5? vs? 7.6±2.2, P<0.01) after the treatment. The curative effect of the observation group was significantly higher than that of the control group (Z=2.008, P=0.045). There were no adverse reactions occurred in the two groups during the treatment.? Conclusion Bixiefenqing pellet is helpful to enhance sperm motility, improve discomfort symptoms and improve curative effect in young soldiers with asthenospermia due to kidney-asthenia combined with wetness-evil.