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Received:July 15, 2018 Published Online:December 21, 2018
Received:July 15, 2018 Published Online:December 21, 2018
中文摘要: 目的 探讨萆薢分清丸对肾虚夹湿型弱精子症青年军人患者的临床疗效。 方法 纳入2016年1月至2017年12月收治的肾虚夹湿型弱精子症青年军人患者90例,随机分为观察组和对照组,每组45例。对照组口服维生素E(100 mg,bid)和左卡尼汀(10 mg,bid),观察组口服萆薢分清丸(6 g,bid)、维生素E(100 mg,bid)和左卡尼汀(10 mg,bid),两组均连续服药治疗12周。通过精液分析仪检测两组治疗前后精液常规(精子活力参数),使用流式细胞仪检测两组治疗前后精子DNA碎片化指数(DFI),采用中医症状积分评估两组治疗前后临床症状改善情况,观察两组总有效率和不良反应情况。 结果 治疗后,观察组精子活力参数中前向运动精子(A级+B级)百分率[(38.1±11.9)%]、快速前向运动精子(A级)百分率[(18.7±5.5)%]较对照组[(33.0±9.7)%,(16.1±4.8)%]显著增加(P<0.05),精子DNA碎片化指数[(14.8±4.2)%]较对照组[(17.1±5.1)%]显著减轻(P<0.05),临床症状积分(5.2±1.5)较对照组(7.6±2.2)显著改善(P<0.01)。观察组疗效明显高于对照组(Z=2.008,P=0.045)。两组治疗过程中均未见不良反应发生。 结论 萆薢分清丸有助于增强肾虚夹湿型弱精子症青年军人患者精子活力,改善不适症状并提高疗效。
Abstract:Objective To investigate the clinical effect of bixiefenqing pellet in young soldiers with asthenospermia due to kidney-asthenia combined with wetness-evil.? Methods A total of 90 young soldiers with asthenospermia due to kidney-asthenia combined with wetness-evil who received treatment from January 2016 to December 2017 were selected and divided into observation group and control group randomly (n=45, each). The control group patients took vitamin E (100 mg, bid) and levocarnitine (10 mg, bid) orally. The observation group patients took bixiefenqing pellet (6 g, bid), vitamin E (100 mg, bid) and levocarnitine (10 mg, bid) orally. Both group was treated for 12 weeks. Semen routine (sperm motility parameters) were measured by sperm morphology analyzer before and after treatment. Sperm DNA fragmentation index (DFI) was measured by flow cytometry before and after treatment. The improvement of clinical symptoms was evaluated by Chinses Medicine symptom integral before and after treatment. The total effective rate and adverse reactions of the two groups were observed.? Results Compared with control group, the percentages of sperm with progressive motility (grade A + grade B) and sperm with fast progressive motility (grade A) in the observation group were significantly higher[(38.1±11.9) %? vs? (33.0±9.7) %, P<0.05; (18.7±5.5) %? vs? (16.1±4.8) %, P<0.05], and the DFI was significantly higher [(14.8±4.2) %? vs? (17.1±5.1) %, P<0.05], and clinical symptoms score was significantly improved (5.2±1.5? vs? 7.6±2.2, P<0.01) after the treatment. The curative effect of the observation group was significantly higher than that of the control group (Z=2.008, P=0.045). There were no adverse reactions occurred in the two groups during the treatment.? Conclusion Bixiefenqing pellet is helpful to enhance sperm motility, improve discomfort symptoms and improve curative effect in young soldiers with asthenospermia due to kidney-asthenia combined with wetness-evil.
keywords: Bixiefenqing pellet Asthenospermia Kidney-asthenia combined with wetness-evil syndrome Young soldier DNA fragmentation index Sperm motility
文章编号: 中图分类号:R 256.5,R 588.1 文献标志码:B
基金项目:解放军福州总医院军事医学研究专项基金(2015J05)
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