Abstract:Objective To investigate the influence of Chuanglingye hydropathic compress on chronic wound surface infected by methicillin-resistant Staphylococcus aureus (MRSA) and local immune inflammatory response in rats.? Methods The animal model of chronic wound was made by dripping MRSA on the wound surface. A total of 30 rats with successful modeling were randomly divided into control group, Chuanglingye group and fusidic acid group (n=10, each). The control group was treated with 4 saline gauze, and the Chuanglingye group was treated with 4 Chuanglingye gauze and the fusidc acid group was treated with 4 fusidc acid gauze on the wound surface, the dressings were changed on each other day. At 3 and 7 days after the treatment, the wound area was determined. The level of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), immunoglobulin (Ig) A and IgG of the wound surface were detected at 7 days after the treatment. Western blot was used to detect the expression of vascular endothelial growth factor (VEGF) of the wound surface.? Results On the 3rd and 7th day after intervention, the wound area of Chuanglingye group and fusidic acid group was smaller than that of control group, and on the 7th day after intervention, the wound area of Chuanglingye group was smaller than that of fusidc acid group (all P<0.05). The level of IgA, IgG and VEGF in Chuanglingye group were significant higher than those in fusidc acid group and control group (all P<0.05).? Conclusion Chuanglingye could significantly reduce the wound area and promote the healing of wound surface infected by MRSA, which may be related to its comprehensive effect of antibacterial, regulating immune-inflammatory factors and promoting the expression of VEGF.