Abstract:Objective To investigate the expression of disabled homolog 2 interacting protein (DAB2IP) in gallbladder carcinoma tissue and its relationship with gallbladder carcinoma clinical pathology. Methods Clinical data was retrospectively analyzed in 72 patients who received cholecystectomy in Affiliated Hospital of Xuzhou Medical University form December 2005 to December 2015. Twenty-seven patients with asymptomatic gallbladder cholesterol polyps as control group, and 45 patients with gallbladder carcinoma as study group. Immunohistochemistry was used to detect the expression of DAB2IP in surgical resection specimens, and the relationship between expression of DAB2IP and tumor clinical pathologic factors was analyzed. The risk factors of gallbladder carcinoma prognosis were studied by Logistic regression analysis. Results The expression of DAB2IP gene in control group normal gallbladder tissue and gallbladder carcinoma tissue were 66. 67% and 31. 11%, respectively(P＜0.05). One-way analysis of variance showed that the expression of DAB2IP was related to the differentiation, depth of invasion of the cancer tissue and lymphatic metastasis(all P＜0.05), butthere was no relationship with gender, age and tumor size(all P＞0.05). Logistic regression analysis showed that the well and intermediate differentiation(OR=3. 51), depth of invasion with stage T1 and T2(OR=1. 25), and with lymphatic metastasis(OR=5. 46), they were risk factors for the advantage prognosis of gallbladder carcinoma. Conclusion The down-regulation of expression of DAB2IP in gallbladder carcinoma tissue may be related to the occurrence, invasion and metastasis of gallbladder carcinoma.