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投稿时间：2024-04-18 网络发布日期：2025-03-20
投稿时间：2024-04-18 网络发布日期：2025-03-20
中文摘要: 带状疱疹相关性疼痛（ZAP）是由带状疱疹病毒导致的周围神经损伤引起的神经病理性疼痛，随着人口老龄化，其发生率逐年增高，往往迁延难愈，已严重影响患者的生活质量，治疗方法多样，疗效和预后也有较大差异。富血小板血浆（PRP）取自自体血，获得途径简单且安全性高，具有神经修复和缓解疼痛的作用。本文就ZAP的发病机制、现有治疗方式和PRP的作用机制，以及当前PRP治疗ZAP的研究进展作一综述，以期为临床利用PRP治疗ZAP提供参考。
Abstract:Zoster-associated pain (ZAP) is neuropathic pain caused by peripheral nerve injury due to herpes zoster virus. With the aging of the population, its incidence is increasing year by year, and it is often prolonged and difficult to cure, which has seriously affected the quality of life of patients. The treatment methods of ZAP are varied, and the therapeutic efficacy and prognosis are also widely different. Platelet-rich plasma (PRP) is derived from autologous blood, which is simple and safe to obtain, and has the effect of nerve repair and pain relief. This article reviews the pathogenesis of ZAP, the existing therapeutic modalities and the mechanism of action of PRP, as well as the current progress of PRP in the treatment of ZAP, with a view to providing a reference for the clinical treatment of ZAP with PRP.
文章编号： 中图分类号：R752.12 文献标志码：A
基金项目:山东省医学会镇痛镇静-麻醉优化专项（YXH2022ZX05274）
附件
| 作者 | 单位 |
| 张文丽 | 1. 山东第二医科大学麻醉学院，山东 潍坊 261000 |
| 葛维鹏 | 2. 胜利油田中心医院疼痛科，山东 东营 257000 |
| 傅志俭 | 3. 山东第一医科大学附属省立医院疼痛科，山东 济南 250021 |
| Author Name | Affiliation |
| ZHANG Wenli*, GE Weipeng, FU Zhijian | *School of Anesthesiology, Shandong Second Medical University, Weifang, Shandong 261000, China |
引用文本：
张文丽,葛维鹏,傅志俭.富血小板血浆治疗带状疱疹相关性疼痛的研究进展[J].中国临床研究,2025,38(3):488-492.
张文丽,葛维鹏,傅志俭.富血小板血浆治疗带状疱疹相关性疼痛的研究进展[J].中国临床研究,2025,38(3):488-492.