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投稿时间：2024-10-16 网络发布日期：2025-03-20
投稿时间：2024-10-16 网络发布日期：2025-03-20
中文摘要: 胰腺癌是一种侵袭性极强且预后极差的恶性肿瘤，现有的治疗方案疗效有限。近年来，随着分子靶向治疗、免疫治疗等新兴治疗手段的发展，胰腺癌的治疗取得了一些进展。本综述重点探讨了几种前沿的治疗策略，包括针对KRAS突变的靶向治疗、DNA损伤修复通路的抑制、免疫检查点抑制剂的应用以及嵌合抗原受体T细胞免疫疗法（CAR-T）在胰腺癌中的前景。此外，文章分析了胰腺癌肿瘤微环境的免疫抑制特征，讨论了新兴治疗手段如抗血管生成药物、代谢治疗和肿瘤疫苗的潜力。
Abstract:Pancreatic cancer is a highly aggressive malignancy with a poor prognosis, and current therapies show limited efficacy. In recent years, with the development of emerging therapies such as molecular targeted therapy and immunotherapy, some progress has been made in the treatment of pancreatic cancer. This review focuses on several cutting-edge therapeutic strategies, including targeted therapies against KRAS mutations, inhibition of DNA damage repair pathways, the application of immune checkpoint inhibitors, and the potential of CAR-T cell therapy in pancreatic cancer. Additionally, the article analyzes the immunosuppressive characteristics of the tumor microenvironment in pancreatic cancer and discusses the potential of emerging treatments such as anti-angiogenic drugs, metabolic therapy, and cancer vaccines.
keywords: Pancreatic ductal adenocarcinoma Targeted therapy Immunotherapy KRAS mutation Tumor microenvironment
文章编号： 中图分类号：R735.9 文献标志码：A
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引用文本：
郭舜尧，孔超，周易，于苏川，陆海艳，肖辛瑶，沈华.晚期胰腺癌靶向治疗与免疫治疗的进展[J].中国临床研究,2025,38(3):483-487.
郭舜尧，孔超，周易，于苏川，陆海艳，肖辛瑶，沈华.晚期胰腺癌靶向治疗与免疫治疗的进展[J].中国临床研究,2025,38(3):483-487.