Abstract:Objective To investigate the application of carbon nanoparticle-labeled sentinel lymph node (SLN) tracing in endometrial cancer surgery, providing a safer and more effective treatment option for clinical practice.Methods A total of 42 patients diagnosed with endometrial cancer by pathology and undergoing standard surgical staging for endometrial cancer via laparoscopic approach at Nanjing Jiangbei Hospital from January 2021 to January 2024 were selected. The preoperative imaging assessment was performed to confirm the lymph node status. During surgery, all patients underwent carbon nanoparticle-labeled SLN tracing, and the detection of SLNs was recorded. The excised lymph nodes were sent for pathological examination postoperatively. Result Among the 42 patients with endometrial cancer, SLNs with dark staining were successfully detected in 38 cases during surgery, with a detection rate of 90.48% (38/42), totaling 165 nodes. The imaged SLNs were mainly distributed in the external iliac (38.79%), obturator (26.67%), common iliac (18.79%), internal iliac (10.30%), and abdominal aortic (5.45%) regions, with none found in the parauterine area. Among the 38 patients, postoperative pathological examination revealed lymph node metastasis in 10 cases (26.32%). The sensitivity of the carbon nanoparticle-labeled SLN tracing technique was 100% (10/10), and the negative predictive value was 100% (28/28). Conclusion The carbon nanoparticle-labeled SLN tracing technique provides a precise tool with high sensitivity and negative predictive value for the diagnosis and treatment of early-stage endometrial cancer, which is conducive to the development of endometrial cancer surgical treatment in a safer and more effectine direction.