本文已被：浏览 35次 下载 23次
投稿时间：2025-01-01 网络发布日期：2025-03-20
投稿时间：2025-01-01 网络发布日期：2025-03-20
中文摘要: 目的 探讨晚期非小细胞肺癌（NSCLC）化疗后，使用白蛋白与碱性磷酸酶比值（AAPR）评估其疗效和预后的意义。方法 回顾性选取2018年10月至2020年10月期间在南京江北医院接受含铂双药化疗的40例晚期NSCLC患者作为研究对象，化疗前检测所有患者白蛋白与碱性磷酸酶水平并计算AAPR。化疗结束后3个月，采用实体瘤疗效评价标准评价疗效，将患者分别分入有效组、无效组。出院后对所有患者进行为期3年的随访，根据随访结果分为预后良好组及预后不良组。分析AAPR与晚期NSCLC患者预后的关系，探讨影响晚期NSCLC患者预后的相关因素。结果 40例晚期NSCLC患者中化疗有效17例，无效23例；预后良好14例，预后不良26例。有效组患者AAPR水平高于无效组（0.67±0.21 vs 0.34±0.13， t=6.127, P<0.05）；晚期NSCLC患者血清AAPR与实体瘤疗效呈正相关（r=0.516，P<0.01）；预后良好组AAPR水平高于预后不良组（0.92±0.12 vs 0.21±0.07， t=23.725, P<0.05）；血清白蛋白、碱性磷酸酶、AAPR评估晚期NSCLC患者预后的受试者工作特征曲线下面积分别为0.748、0.825、0.913。多因素回归分析显示，东部肿瘤协作组（ECOG）评分≥2分（OR=3.089， 95%CI：1.473~6.481），低分化程度（OR=2.123 95%CI：1.324~3.405），AAPR＜0.51（OR=4.604，95%CI：1.986~10.674）是影响晚期NSCLC患者化疗后预后不良的危险因素（P<0.05）。结论 AAPR与晚期NSCLC患者化疗疗效以及预后密切相关，并对晚期NSCLC患者化疗后预后评估具有较高的价值。
中文关键词: 晚期非小细胞肺癌 白蛋白与碱性磷酸酶比值 化疗 白蛋白 碱性磷酸酶
Abstract:Objective To investigate the significance of using the albumin-to-alkaline phosphatase ratio (AAPR) in evaluating the efficacy and prognosis of advanced non-small cell lung cancer (NSCLC) after chemotherapy. Methods A total of 40 patients with advanced NSCLC who underwent platinum-based doublet chemotherapy at Nanjing Jiangbei Hospital from October 2018 to October 2020 were selected retrospectively as study subjects. The levels of albumin and alkaline phosphatase were measured, and the AAPR was calculated before chemotherapy for all patients. Three months after the completion of chemotherapy, the therapeutic efficacy was evaluated based on solid tumor response criteria, categorizing patients into effective and ineffective groups. All patients were followed up for 3 years after discharge, divided into favorable and poor prognosis groups based on follow-up results. The relationship between AAPR and prognosis in patients with advanced NSCLC was analyzed, and factors affecting the prognosis of these patients were explored. Results Among the 40 patients with advanced NSCLC, 17 had effective chemotherapy, while 23 did not; 14 had a favorable prognosis, and 26 had an unfavorable prognosis. The AAPR level in the effective group was higher than that in the ineffective group (0.67±0.21 vs 0.34±0.13, t=6.127, P<0.05). There was a positive correlation between serum AAPR and solid tumor response in patients with advanced NSCLC (r=0.516, P<0.01). The AAPR level in the favorable prognosis group was higher than that in the poor prognosis group (0.92±0.12 vs 0.21±0.07, t=23.725, P<0.05). The areas under the receiver operating characteristic curve for serum albumin, alkaline phosphatase, and AAPR in assessing the prognosis of patients with advanced NSCLC were 0.748, 0.825, and 0.913, respectively. Multivariate regression analysis showed that an Eastern Cooperative Oncology Group (ECOG) score ≥2 (OR=3.089, 95%CI: 1.473-6.481), low differentiation degree (OR=2.123, 95%CI: 1.324-3.405), and AAPR <0.51 (OR=4.604, 95%CI: 1.986-10.674) were risk factors for poor prognosis in patients with advanced NSCLC, after chemotherapy (P<0.05). Conclusion AAPR is closely related to the therapeutic efficacy and prognosis of patients with advanced NSCLC, and has high value in assessing the prognosis of these patients after chemotherapy.
keywords: Advanced non-small cell lung cancer Albumin-to-alkaline phosphatase ratio Chemotherapy Albumin Alkaline phosphatase
文章编号： 中图分类号：R734.2 文献标志码：A
基金项目:
附件
| Author Name | Affiliation |
| GAO Jinfeng，HU Ping | Oncology Department of Nanjing Jiangbei Hospital Affiliated to Xinglin College, Nantong University, Nanjing，Jiangsu 210048, China |
引用文本：
高金锋，胡萍.白蛋白与碱性磷酸酶比值评估晚期非小细胞肺癌化疗疗效和预后的意义[J].中国临床研究,2025,38(3):379-382,388.
高金锋，胡萍.白蛋白与碱性磷酸酶比值评估晚期非小细胞肺癌化疗疗效和预后的意义[J].中国临床研究,2025,38(3):379-382,388.