Abstract:In cold regions, plateau and high altitude, polar environment and extreme conditions, frostbite not only causes redness, swelling and pain in the frostbite site, but also leads to necrosis and amputation in severe cases. The establishment of stable and reliable animal models of frostbite is cruial to the study of the pathogenesis characteristics and treatment methods of frostbite. At present, there are few relevant research of frostbite animal model widely, and a single frostbite modeling method cannot meet the needs of the researchs of frostbite pathogenesis and clinical treatment. It is necessary to seek a more comprehensive and detailed frostbite modeling method. This article reviews the research progress of frostbite animal modeling methods and the selection of frostbite sites at home and abroad, in order to provide an ideal animal modeling method for frostbite related research.